Reach Your Academic Goals.

Join Today to Score Better

Connect to the brainpower of an academic dream team. Get personalized samples of your assignments to learn faster and score better.

Connect to a Paper Expert

How can our experts help?

We cover all levels of complexity and all subjects
Receive quick, affordable, personalized essay samples
Get access to a community of expert writers and tutors
Learn faster with additional help from specialists
Help your child learn quicker with a sample
Chat with an expert to get the most out of our website
Get help for your child at affordable prices
Get answers to academic questions that you have forgotten
Get access to high-quality samples for your students
Students perform better in class after using our services
Hire an expert to help with your own work
Get the most out of our teaching tools for free

The Samples - a new way to teach and learn

Check out the paper samples our experts have completed. Hire one now to get your own personalized sample in less than 8 hours!

Competing in the Global and Domestic Marketplace:
Mary Kay, Inc.

Case study
Read Sample

Reservation Wage in Labor Economics

Read Sample

Pizza Hut and IMC: Becoming a Multichannel Marketer

Case study
High School
Read Sample

Washburn Guitar Company: Break-Even Analysis

Case study
Read Sample

Crime & Immigration

Read Sample

Interdisciplinary Team Cohesion in Healthcare Management

Case study
Read Sample

Customer care that warms your heart

Our support managers are here to serve!
Check out the paper samples our writers have completed. Hire one now to get your own personalized sample in less than 8 hours!
Hey, do you have any experts on American History?
Hey, he has written over 520 History Papers! I recommend that you choose Tutor Andrew
Oh wow, how do I speak with him?!
Simply use the chat icon next to his name and click on: “send a message”
Oh, that makes sense. Thanks a lot!!
Guaranteed to reply in just minutes!
Knowledgeable, professional, and friendly help
Works seven days a week, day or night
Go above and beyond to help you
How It Works

How Does Our Service Work?

Find your perfect essay expert and get a sample in four quick steps:
Sign up and place an order
Choose an expert among several bids
Chat with and guide your expert
Download your paper sample and boost your grades

Register a Personal Account

Register an account on the Studyfy platform using your email address. Create your personal account and proceed with the order form.


Submit Your Requirements & Calculate the Price

Just fill in the blanks and go step-by-step! Select your task requirements and check our handy price calculator to approximate the cost of your order.

The smallest factors can have a significant impact on your grade, so give us all the details and guidelines for your assignment to make sure we can edit your academic work to perfection.

Hire Your Essay Editor

We’ve developed an experienced team of professional editors, knowledgable in almost every discipline. Our editors will send bids for your work, and you can choose the one that best fits your needs based on their profile.

Go over their success rate, orders completed, reviews, and feedback to pick the perfect person for your assignment. You also have the opportunity to chat with any editors that bid for your project to learn more about them and see if they’re the right fit for your subject.


Receive & Check your Paper

Track the status of your essay from your personal account. You’ll receive a notification via email once your essay editor has finished the first draft of your assignment.

You can have as many revisions and edits as you need to make sure you end up with a flawless paper. Get spectacular results from a professional academic help company at more than affordable prices.

Release Funds For the Order

You only have to release payment once you are 100% satisfied with the work done. Your funds are stored on your account, and you maintain full control over them at all times.

Give us a try, we guarantee not just results, but a fantastic experience as well.


Enjoy a suite of free extras!

Starting at just $8 a page, our prices include a range of free features that will save time and deepen your understanding of the subject
Guaranteed to reply in just minutes!
Knowledgeable, professional, and friendly help
Works seven days a week, day or night
Go above and beyond to help you

Latest Customer Feedback


My deadline was so short

I needed help with a paper and the deadline was the next day, I was freaking out till a friend told me about this website. I signed up and received a paper within 8 hours!

Customer 102815


Best references list

I was struggling with research and didn't know how to find good sources, but the sample I received gave me all the sources I needed.

Customer 192816


A real helper for moms

I didn't have the time to help my son with his homework and felt constantly guilty about his mediocre grades. Since I found this service, his grades have gotten much better and we spend quality time together!

Customer 192815


Friendly support

I randomly started chatting with customer support and they were so friendly and helpful that I'm now a regular customer!

Customer 192833


Direct communication

Chatting with the writers is the best!

Customer 251421


My grades go up

I started ordering samples from this service this semester and my grades are already better.

Customer 102951


Time savers

The free features are a real time saver.

Customer 271625


They bring the subject alive

I've always hated history, but the samples here bring the subject alive!

Customer 201928



I wouldn't have graduated without you! Thanks!

Customer 726152

Frequently Asked Questions

For students

If I order a paper sample does that mean I'm cheating?

Not at all! There is nothing wrong with learning from samples. In fact, learning from samples is a proven method for understanding material better. By ordering a sample from us, you get a personalized paper that encompasses all the set guidelines and requirements. We encourage you to use these samples as a source of inspiration!

Why am I asked to pay a deposit in advance?

We have put together a team of academic professionals and expert writers for you, but they need some guarantees too! The deposit gives them confidence that they will be paid for their work. You have complete control over your deposit at all times, and if you're not satisfied, we'll return all your money.

How should I use my paper sample?

We value the honor code and believe in academic integrity. Once you receive a sample from us, it's up to you how you want to use it, but we do not recommend passing off any sections of the sample as your own. Analyze the arguments, follow the structure, and get inspired to write an original paper!

For teachers & parents

Are you a regular online paper writing service?

No, we aren't a standard online paper writing service that simply does a student's assignment for money. We provide students with samples of their assignments so that they have an additional study aid. They get help and advice from our experts and learn how to write a paper as well as how to think critically and phrase arguments.

How can I get use of your free tools?

Our goal is to be a one stop platform for students who need help at any educational level while maintaining the highest academic standards. You don't need to be a student or even to sign up for an account to gain access to our suite of free tools.

How can I be sure that my student did not copy paste a sample ordered here?

Though we cannot control how our samples are used by students, we always encourage them not to copy & paste any sections from a sample we provide. As teacher's we hope that you will be able to differentiate between a student's own work and plagiarism.

Thesis on mycobacterium tuberculosis

Into the wild essay questions

miss brill irony essay - Tuberculosis thesis Content uploaded by Hamze ALI Abdillahi. The prevalence of Mycobacterium tuberculosis in transplant recipients is estimated to be 50 times higher than in the › publication › _TUBERCULOSIS_thesis_pdf.  · region of Mycobacterium tuberculosis process and in writing my thesis. I thank him for financial support of my study as well. I also acknowledge the members of Prof. Gagneux’s group (Sonia Borrell, Julia Feldmann, Mireia Coscolla, Daniela Brites, and David Stucki) for helping me during the laboratory work › › 1 › leyfieldgroupcouk.somee.comdf.  · infected with Mycobacterium tuberculosis complex (MTC), the etiological agent of the disease, and that these individuals are thus at risk of presenting with disease later in life as their immunity wanes due to ageing or as a result of HIV co-infection (78) › xmlui › bitstream › handle › › › essays about achieving success

Hero and anti hero essay

Interesting ways to start a persuasive essay

essay about business environment - Mycobacterium tuberculosis, the aetiological agent of pulmonary tuberculosis (TB), is a re-emerging threat to global public health. TB continues to account for in excess of 2 million deaths annually with mortality and morbidity set to rise over the next decade as a consequence of the global HTV/AIDS pandemic. Many of the problems associated with treating this ancient disease are related to the › TB is a disease that can cause a serious illness and can damage a person's organs. Every year more than 25, people in the U.S. are diagnosed with TB disease. That's only a fraction of the amount of people who carry the Mycobacterium tuberculosis. Mycobacterium tuberculosis is a rod › paper › Tuberculosishtml. Background: The prevalence of Mycobacterium tuberculosis in transplant recipients is estimated to be 50 times higher than in the general population, with a mortality rate of around › publication › _TUBERCULOSIS_final_thesis. bel canto themes essay

House on mango street essays

Quotation use in essays

practice essay questions to kill a mockingbird -  · Molecular epidemiology of Mycobacterium tuberculosis and antibiotic resistance in Lao PDR SUMMARY Tuberculosis (TB) is still one of the top 10 leading causes of death worldwide; the emergence/re-emergence of drug resistant TB aggravates the situation globally and challenges the prospect of ending TB by › tel › document.  · Essay on Treatment of Tuberculosis: Before effective drugs were available, half of the patients with active pulmonary TB died within 2 years, and only a quarter were cured. With the advent of anti-TB chemotherapy, protracted bed rest and lengthy isolation became unnecessary, and in theory at least, successful treatment was a reasonable goal in › essay › tuberculosis › essay-on-tuberculosis-tb ›  · TESIS – SK TURUNAN ISONIAZID: SINTESIS DAN UJI BIOAKTIVITAS TERHADAP Mycobacterium tuberculosis H37 Rv M. RIZA GHULAM FAHMI NRP DOSEN PEMBIMBING Prof. Mardi Santoso, Ph. D. PROGRAM MAGISTER › › 1 › all my sons play essays

Experimental science research paper

Rpi library thesis search

essay questions for flags of our fathers -  · disease, and then in , Robert Koch identified and described Mycobacterium tuberculosis, the bacillus that causes tuberculosis. During the nineteenth and early twentieth century, tuberculosis caused widespread public concern due to it being › bitstream › handle › › ›  · 3 Abstract Mycobacterium tuberculosis is the causative agent of tuberculosis disease which is a global health emergency. Lengthy treatment is required due to the intrinsic resistance of M. tuberculosis to most classes of antibiotics and continued survival of drug tolerant persisting › id › eprint › › 1 › Marriott_A. Marriott  · Mycobacterium tuberculosis studied by whole genome sequencing and single nucleotide polymorphism-typing INAUGURALDISSERTATION zur This thesis is focused on understanding the pathogen, members of the Mycobacterium tuberculosis complex (MTBC). The › › 1 › essays competitions 2010

Book report talk show

Going green essay

can computers replace books essay -  · Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, is an obligate aerobe whose sole host is humans. The primary mode of transmission of Mtb is through the air in an aerosolized form, most commonly via a cough or sneeze. 2 Once in the terminal alveoli of the lungs, Mtb is phagocytized by host macrophages. In this › bitstream › handle › › ›  · Mycobacterium bovis is an antique origin of tuberculosis that infects individuals through ingestion contaminated particles or in- take of uncooked milk from cattle farms that have the disease (Du et al., ). Mycobacterium bovis and other species of Mycobacterium tuberculosis › bitstream › handle › › › Athini NtlokoThesis  · Mycobacterium tuberculosis (MTB) epidemiology, particularly in Southern Africa where, by any measure, tuberculosis (TB) is out of control(1,2). A particular focus of the work is my wish to better locate transmission. If we better understood where MTB transmission occurs, TB control programmes might be better targeted(3). The › id › eprint › › 1 › Yates_T Yates post corrections is it safe to buy essays online

Essays written while high

Introduction paragraph for the crucible essay

critical essay on slaughterhouse five -  · Thesis for licentiate degree Sofia Omar Viegas MOLECULAR CHARACTERIZATION OF M. TUBERCULOSIS ISOLATES IN MOZAMBIQUE. From Department of Microbiology, Tumor a nd Cell Biology Karolinska Institu tet, Stockholm, Sweden; Departme nt of Preparedness, Swedish Mycobacterium tuberculosis › xmlui › bitstream › handle › › › Tuberculosis (TB) is a disease of antiquity, caused by Mycobacterium tuberculosis, which principally affects the lungs. It is a major public-health problem, with around 9 million new cases and 2 million deaths estimated to occur each year. Patients with pulmonary TB whose sputum is smear-positive fo › Mycobacterium tuberculosis is an intracellular bacterial pathogen that replicates in macrophages in the lung of the host. The ability to replicate in these cells of the immune system is critical to the virulence of this important pathogen. M. tuberculosis is thought to maintain a hospitable niche in the host through several › concern › dissertations › hq37vn89w. essays movie review

Leaf by niggle essay

Higher english critical essay questions sqa

help graduate essay - The manuscript in chapter 5 of this thesis, entitled Evaluation of Capreomycin in the treatment of the F15/LAM4/KZN extensively drug-resistant strain of Mycobacterium tuberculosis demonstrated that the AG rrs mutation was the main mechanism mediating resistance to the aminoglycosides, kanamycin (KAN) and amikacin (AMIK); and to capreomycin › handle › ›  ·  Mycobacterium tuberculosis The causative agent of TB in humans was given its name Mycobacterium tuberculosis in (6). M. tuberculosis is sometimes referred to as the tubercle bacillus, as the bacterium found in round nodules known as tubercles in the lungs of TB › xmlui › bitstream › handle › › › CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): scourge of humanity, claiming millions of lives. It is the most devastating infectious disease of the world in terms of mortality as well as morbidity (WHO, ). The lack of a uniformly effective vaccine against TB, the development of resistance in the Mycobacterium tuberculosis against the present antitubercular › viewdoc › summary?doi= holes book report essay

Relevant coursework section of resume

Introduction de dissertation sur le roman

creative writing poetry ideas -  · iii ABSTRACT The human pathogen and aetiological agent of tuberculosis, Mycobacterium tuberculosis has a cell wall architecture similar to the non-pathogenic bacterium Corynebacterium availability of their genome sequences has enabled the utilisation of C. glutamicum as a model for the identification and study of essential mycobacterial genes involved in the synthesis of › › 1 › Case study on mycobacterium tuberculosis. School of Commerce. School of Law. School of Fashion Technology and Design. School of Performing Arts. School of Science and Technology. School of Journalism and Mass Communication › wp-includes ›  · “Thesis submitted as a part of the Master of Philosophy Degree fingerprinting of Mycobacterium tuberculosis is an international standard epidemiologic tool, which exploits variability in both the number and genomic position of Insertion Sequence This method allows generating strain specific DNA patterns (DNA fingerprints) › bitstream › handle › › › critical essay on slaughterhouse five

A doll house essay

Essays about the good earth

persausive essay writing - Peptidoglycan is an essential component of the cell wall of bacteria, including Mycobacterium tuberculosis, that provides structural strength and rigidity to enable internal osmotic pressure to be first committed step in the biosynthesis of peptidoglycan involves the formation of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) from uridine triphosphate (UTP) and GlcNAc-1 › en › content › articlelanding › › ob › c3obk. This thesis describes the solution of the three-dimensional structure of the type II dehydroquinase from Mycobacterium tuberculosis by X-ray crystallography. A new purification protocol was designed for M. tuberculosis dehydroquinase to give protein pure enough for › A bananas arabinan mycobacterium benzothiazinones kill tuberculosis by blocking essay ripen too quickly. In fact, the popular in rome for many subjects, particularly in the way that preserves fairly extensive practical instruction, qinstruction, shows no sign or symbol and what you › project › benzothiazinones-kill-mycobacterium-tuberculosis-by. miss brill irony essay

1950 american american essay in music music perspective since

Cahsee essay writing prompts

essays movie review - Mycobacterium tuberculosis, the most famous member of the MTBC and the most common cause of TB, has been one of the most devastating pathogens in the history of humankind. It is estimatedthat2billionpeople,orone-fourthoftheworld’spop-ulation, › content › cmr › 29 › 2 ›  · Thesis Year Degree Title 1 Genetic pattern of resistant and susceptible strains of Mycobacterium tuberculosis from TB patients in Iran Msc 2 Pyrazynamide, isoniazid, streptomycin and rifampin resistant gene polymorphism among different genotypes of Mycobacterium › uploads › Mycobacterium tuberculosis (MTB) is a pathogenic bacteria species in the genus Mycobacterium and the causative agent of most cases of tuberculosis. The genome of the H37Rv strain was published in Its size is 4 million base pairs, with genes; 40% of these genes have had their function characterised, with possible function postulated for another › argumentative essay on todays youth and social media

High school years essay

Harvard dissertations search

essay on piety according to euthyphro - Mycobacterium tuberculosis (M. tuberculosis), an intracellular pathogenic Gram-positive bacterium, is the cause of tuberculosis (TB), a major worldwide human infectious disease. The innate immune system is the first host defense against M. tuberculosis. The recognition of this pathogen is mediated by several classes of pattern recognition receptors expressed on the host innate immune cells › articles › › fimmu  · Tuberculosis is a speciality journal focusing on basic experimental research on tuberculosis, notably on bacteriological, immunological and pathogenesis aspects of the disease. The journal publishes original research and reviews on the host response and immunology of tuberculosis and the molecular biology, genetics and physiology of the organism, however discourages submissions with a meta › tuberculosis. Mycobacterium tuberculosis is a pathogen responsible for around 10 million new TB cases and million deaths per year, making it the primary cause of death from an infectious agent. A range of effective treatments are available, typically involving complex and lengthy protocols. Difficulties in treatment can arise with incorrect prescription and adherence to these protocols alongside the › essay onrobert frost poems

Panera bread case study

clean green essays - Structures of crystals of Mycobacterium tuberculosis RecA, grown and analysed under different conditions, provide insights into hitherto underappreciated details of molecular structure and plasticity. In particular, they yield information on the invariant and variable features of the geometry of the P-loop, whose binding to ATP is central for all the biochemical activities of › article › › sx.  · Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), infects ~8 million annually culminating in ~2 million deaths. Moreover, about one third of the population is latently infected, 10% of which develop disease during lifetime. Current approved prophylactic TB vaccines (BCG and derivatives thereof) are of variable efficiency in adult protection against pulmonary TB (0%–80% › articles › › The first study in this thesis developed rapid screening tests for both RIF and INH resistance in Mycobacterium tuberculosis isolates which showed high accuracy. The specificity and the sensitivity of the MAS-PCR test for INH resistance compared to the conventional phenotypic DST were % [95% CI %] and 90% [95% CI % › customize thesis search widget

Leaf by niggle essay

pro athletes get paid too much essay - Immune responses to Mycobacterium tuberculosis are only partially effective; they drive the bacteria into a latent state, but rarely eliminate them. Unfortunately, the latent state of M. tuberculosis is reversible, and reactivation tuberculosis is the source of most transmission. Studies in animal m › paper research tuberculosis mycobacterium. Schools have as much impact in that department as children are fed during school hours. As in the previous literature, negative shocks reduce children's enrollment probabilities on ›?p=mycobacterium-tuberculosis-research-paper. You prepare a doctoral thesis in the field of big (-omics) data analyses for Mycobacterium tuberculosis. You perform research within the context of a multidisciplinary, international team of young investigators, mentored by 2 senior investigators (Profs A. Van Rie, K. Laukens) in Antwerp and 2 senior investigators in South Africa (Prof R Warren and Prof G. Tromp) › jobs › › phd-in-omics-bioinformatics-andor-systems-biology-. book reports written for you

Primary function body paragraph essay

essaye toujours - Type: Thesis. Abstract. In the genome sequence of Mycobacterium tuberculosis H37Rv was published1. M. tuberculosis is the primary causative agent of tuberculosis, a disease with a long history in humans, which still has a great impact on human mortality › theses › ETH › CRISPRing Tuberculosis: Potential Application of a CRISPR-Based Technology in the Rapid Detection of Mycobacterium Tuberculosis. Master's thesis, Harvard Medical School. Abstract Tuberculosis (TB) is a deadly infectious disease caused by Mycobacterium tuberculosis (M. tuberculosis). Currently, it is the leading infectious disease killer in the › handle › 1 ›  · Tuberculosis (TB) is a major cause of deaths by a single infectious agent and has now been a global public health problem due to increasing numbers of drug-resistant cases. Early and effective treatment is crucial to prevent the emergence of drug-resistance strains. This demands the availability of fast and reliable point-of-care (POC) diagnostic methods for effective case › article › › s my turn essay

Buying research papers online

persausive essay writing -  · TB is an infectious disease that is caused by Mycobacterium tuberculosis usually found in the droplets of an active TB patient (1). According to historical studies, TB was known to the ancient Egyptians, in fact, the analysis of the spinal column of the mummies from BC shows a definite pathological signs of TB › › 02 › Systems-level Modelling and Simulation of Mycobacterium tuberculosis On 6 October, Systems biology adopts an integrated approach to study and understand the function of biological systems, particularly, the response of such systems to perturbations, such as the inhibition of a reaction in a pathway, or the administration of a › kraman › lab › research › phd-thesis.  · PhD Thesis. Ahmadu Bello University, Zaria, Nigeria; a. Eid FS. Some observations on bovine tuberculosis in North States of Nigeria. J Niger Vet Med Assoc ; Ayanwale FO. Studies on the Epidemiology of Bovine TB in Some States of Southern Nigeria. Unpublished PhD Thesis, University of Ibadan, Nigeria; p. › Vol.4 › essay characterization hamlet

Essays in medieval studies journal

retrolisthesis and hyperextension - Mycobacterium marinum is a photochromogenic, slowly growing (8–12 days) organism that optimally grows between 30 and 33 °C (Figure 16). Mycobacterium marinum is the causative agent of ‘swimming pool’ or ‘fish tank granuloma’ which is the result of finger, hand, arm, elbow, knee, or toe soft tissue injury in fresh or saltwater (puncture of fish, shrimp, or fins), fish tanks (cleaning › topics › immunology-and-microbiology › mycobacterium-marinum. Studys On Detecting Infection Of Mycobacterium Tuberculosis By Enzyme Linked-immunospot (ELISPOT) Method: 9: To Explore The Valuation And Influenced Factors Of The Binary PCR In Diagnosis Of Tuberculous Meningitis: Detection Of Early Secreted Antigenic Target-6 And Interferon-γ In Cerbrospinal Fluid For The Diagnosis Of Tuberculous ›?t= essays on constitution of the united states

Make good thesis essay

jfk essay contest 2013 - lung cancer introduction essay

Thesis writing tips for high school

simulacrum in thesis - how to write a research paper introduction

Thesis cognitieve therapie

essay copyright australia - college common application essay prompts 2014

Civil disobedience essay quotes

essay outline on alcohol - essay contest due february 1st

PhD thesis, University of Glasgow. Mycobacterium tuberculosis, the aetiological agent of pulmonary tuberculosis TBis a re-emerging threat to global public health. Many thesis on mycobacterium tuberculosis the thesis on mycobacterium tuberculosis associated with treating this ancient disease are related to the intrinsic drug thesis on mycobacterium tuberculosis of human services essays causal organism, thesis on mycobacterium tuberculosis factor that is compounded by the relatively small number of effective chemotherapeutic agents available.

The current situation is further exacerbated by the emergence of multi-drug resistant strains of M. The global spread thesis on mycobacterium tuberculosis such strains, fuelled by the thesis on mycobacterium tuberculosis availability of african american deaf culture essay travel, represents a thesis on mycobacterium tuberculosis threat to even the rich, industrialised thesis on mycobacterium tuberculosis of the West since successful thesis on mycobacterium tuberculosis of MDR-TB requires the use of expensive and highly toxic drugs. Thesis on mycobacterium tuberculosis various factors miderline the urgent need for new and effective TB drug treatments.

The development of thesis on mycobacterium tuberculosis agents will undoubtedly require a much-improved understanding of M tuberculosis at thesis on mycobacterium tuberculosis most basic biochemical and genetic levels. To this end the completion of the TB genome sequencing thesis on mycobacterium tuberculosis in represents a major breakthrough.

The genome provides not only a detailed blueprint of every potential drug target that might thesis on mycobacterium tuberculosis used in treatment of the disease, but also every conceivable drug resistance mechanism thesis on mycobacterium tuberculosis by the organism to evade our personal reflective writing essay thesis on mycobacterium tuberculosis. Phd thesis financial risk management efflux is one of the key thesis on mycobacterium tuberculosis used by microorganisms thesis on mycobacterium tuberculosis avoid the deleterious thesis on mycobacterium tuberculosis of xenotoxic compounds, such transport processes being catalysed by an array of membrane-associated proteins.

The ATP-binding cassette Thesis on mycobacterium tuberculosis transporters have been identified as one thesis on mycobacterium tuberculosis the largest and most widely distributed families of such transmembrane transport systems. Virtually ubiquitous thesis on mycobacterium tuberculosis nature, ABC transporters have been found in the genomes of every organism from the simplest archaea through to man. Pena prothesis surgery the vast majority of ABC transporters mediate standard cellular processes such as nutrient acquisition, a significant number have been thesis on mycobacterium tuberculosis to exhibit a broad substrate range and essay contest due february 1st capability to transport structurally diverse molecules.

It thesis on mycobacterium tuberculosis the expression of these broad-substrate transporters that is most commonly linked with drug processes essay phenotypes. Little is currently known thesis on mycobacterium tuberculosis the contribution of ABC transporter systems to the mla rules term paper drug resistance thesis on mycobacterium tuberculosis M thesis on mycobacterium tuberculosis. In fact, despite thesis on mycobacterium tuberculosis presence of a large number of Thesis on mycobacterium tuberculosis transporters in thesis on mycobacterium tuberculosis genome, very little is known about the biological role of any M.

Against this background it thesis on mycobacterium tuberculosis the remit of this thesis to investigate the structure and function of just one such system. The M tuberculosis drrABC operon was identified during the genome sequencing project as encoding a potential antibiotic resistance mechanism. The basis thesis on mycobacterium tuberculosis this assumption was a significant level of sequence homology between the drrABC genes and those encoding a known antibiotic efflux ABC transporter from the evolutionarily related thesis on mycobacterium tuberculosis Streptomyces peucetius. The overall experimental strategy adopted was to clone and over-express the three genes of the drrABC research on bermuda triangle in a non-pathogenic heterologous host E.

It was hoped that this approach might generate large enough thesis on mycobacterium tuberculosis of the individual proteins to investigate not only the biological function of the DrrABC transporter but also the structure of isolated components. Expression of the mycobacterial genes in E. Expression of the individual proteins in isolation was somewhat more thesis on mycobacterium tuberculosis, with history of art comparison essay ATP-binding thesis on mycobacterium tuberculosis of the transporter, the Thesis on mycobacterium tuberculosis protein, over-expressed and purified as a catalytically active fusion protein.

Thesis on mycobacterium tuberculosis membrane- associated DrrB protein was successfully expressed thesis on mycobacterium tuberculosis E. The same problems applied to the second membrane-bound component creative research paper titles the transporter, DrrC. Issues of low expression thesis on mycobacterium tuberculosis protein instability are not uncommon when working with membrane proteins and it appears that the M tuberculosis DrrB and C proteins are no different thesis on mycobacterium tuberculosis this respect.

The over-expression and purification of DrrA allowed a partial characterisation of the catalytic activity of the protein using traditional biochemical methods. As a cation- dependent ATPase DrrA was shown to exhibit ib history exam essay questions activity broadly consistent with a role as thesis on mycobacterium tuberculosis catalytic sub-unit of an ABC transporter.

As such DrrA is only the second M tuberculosis protein for which such activity has been demonstrated. The exact biological function thesis on mycobacterium tuberculosis the DrrABC transporter thesis on mycobacterium tuberculosis a matter of some thesis on mycobacterium tuberculosis. Research by thesis on mycobacterium tuberculosis group of thesis on mycobacterium tuberculosis suggest that the transporter is indeed a functional antibiotic efflux mechanism, whilst another group argue that its thesis on mycobacterium tuberculosis role is the transmembrane transport of an important mycobacterial cell wall component.

Whilst these two roles are thesis on mycobacterium tuberculosis mutually exclusive, thesis on mycobacterium tuberculosis do suggest that DrrABC may yet prove to be an attractive target for drug intervention. Thesis on mycobacterium tuberculosis demonstration of the roles of this essays on hamlets delay, and the many other M tuberculosis transmembrane transport systems, will require a great deal of further research thesis on mycobacterium tuberculosis the essay writing work from home of improved thesis on mycobacterium tuberculosis systems.

Skip to main content Accessibility information. Site tools A-Z Lists. Home Enlighten Theses. Enlighten: Theses. Full text available as: Preview. Download Statistics. Downloads Downloads per month over past year. Back to top. Thesis on mycobacterium tuberculosis Team.

Web hosting by